Drivers warned of long tailbacks in the area.
UPDATE: The road was re-opened to traffic shortly before 7pm.
Police have closed part of the A361 North Devon Link Road following a crash at the Landkey junction this evening (Monday).
The collision between a Ford Transit van and a Ford S-Max was reported to police shortly after 5.30pm.
A police spokesperson said there were no reported injuries but both carriageways have been closed between the junction and the Portmore roundabout in Barnstaple.
Motorists are being advised to avoid the area due to long tail backs in both directions.
The road is expected to remain closed until later this evening to enable the recovery of the vehicles.