More than six police cars, accompanied by a police helicopter and air ambulance, responded to the call made just before 1pm.
The collision involved a tractor and pick-up truck.
Police are currently searching for Steven Gregory, aged 36.
The incident happened near the roundabout leading Victoria Road, Forches Avenue and Constitution Hill.
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The collision between several vehicles happened shortly after 2pm - motorists faced 20 minute delays.
The incident occurred between J27 and J26 near Tiverton.
Westacott Road has now reopened following police investigation work.
Keith Beviss, 54, of Honiton appeared at Exeter Magistrates court charged with the murder of Philip Ryan from Westward Ho!
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